These results exhibit sufficiency of TAZ activation for driving fibroblast proliferation, contraction, and soluble profibrotic factor expression, and mechanical context-dependent crosstalk of TAZ with other pathways in regulating Col1a1Almost never you might have a rash that doesn’t recuperate. You may notice pink or darkish crimson patches that
Recent reports have implicated the Hippo pathway and its transcriptional effectors YAP and TAZ as needed for fibroblast activation and tissue fibrosis. To test the particular and adequate roles for TAZ in driving autonomous fibroblast activation, we cultured NIH3T3 fibroblasts expressing a doxycycline-inducible nuclear-localized mutant of TAZ (TAZ4
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